Photosensitizing medications and photocarcinogenesis
نویسندگان
چکیده
منابع مشابه
Photoimmune suppression and photocarcinogenesis.
The primary cause of non-melanoma skin cancer, the most prevalent form of human neoplasia, is the ultraviolet (UV) radiation found in sunlight. Exposing mice to UV radiation induces skin cancers that are highly antigenic. Upon transfer of an UV-induced skin cancer to a normal syngeneic mouse, the tumor cells are recognized and rapidly destroyed by the immune system of the recipient. This raises...
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Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. We previously showed that irradiance plays a critical role in UVB-induced cell differentiation....
متن کاملPhotocarcinogenesis--molecular mechanisms.
The carcinogenicity (photocarcinogenicity) of sunlight to human skin has been recognized more than a century ago. Last decades numerous experimental studies show that UV rays damage DNA, cause gene mutations leading to the development of malignant tumors such basal cell carcinomas, squamous cell carcinomas and melanomas. The tumors occur most frequently in fair skinned people, and the mutations...
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Taking medications during breastfeeding is common and physicians are usually asked about the safety of prescribed medicines, herbal medications, or tobacco and alcohol consumption during lactation. Safety of medications during breastfeeding is related to maternal factors, neonatal factors and the type of medication, In the case of necessity of taking medication for the mother, there are ways to...
متن کاملMolecular mechanisms of photocarcinogenesis.
Photocarcinogenesis represents the accumulation of genetic changes as well as immune system modulation, which ultimately lead to the development of skin cancers. The recent advances in molecular and cellular biology have clarified the mechanisms of photocarcinogenesis, including the formation of DNA photoproducts, DNA repair, mutation of proto-oncogenes and tumor suppressor genes, and UV-induce...
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ژورنال
عنوان ژورنال: Photodermatology, Photoimmunology & Photomedicine
سال: 2013
ISSN: 0905-4383
DOI: 10.1111/phpp.12085